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All tags for this page:Chemokines are a superfamily of small secreted peptides
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aegnusray: Chemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine...
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Chemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
Chemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
folkd this page
on 11/24/2010 11:36pmChemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
folkd this page
on 12/27/2010 12:04amChemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
folkd this page
on 01/24/2011 09:26pmChemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
folkd this page
on 02/25/2011 12:03amChemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
Chemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
Chemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
Chemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
Chemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
Chemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
Chemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
Chemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
Chemokines are derived from their ability to induce directed chemotaxis in nearby responsive cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8 ~ 10 kD.
Current knowledge of chemokine biology should propel the field toward a better understanding of the contribution that chemokine dysregulation makes to chronic inflammation, excess or impaired angiogenesis, and, equally important but more challenging, their role in pathological wound healing. One can use modified antagonists of the proteins themselves or of their N-termini; use monoclonal antibodies directed either to a specific chemokine or to its receptor; and use small molecules that inhibit their receptors. Available information in preclinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.
The ability of chemokines to enhance the motility of leukocytes, endothelial cells, and/or tumour cells is a key factor in determining the cancer establishment and progression. Depending on their specific expression pattern on target cells, on tumour type and on tumour microenvironment factors, several chemokines support malignancy, while others can at times inhibit this process. On the basis of these evidences, the characterization of the different chemokine networks in various types of cancer cells may foster better knowledge for understanding the immune-related mechanisms of cancer development and application in cancer immunotherapy.